Anti-PHOX2A monoclonal antibody, clone 5G7

Antibody Isotype

IgG2a

Clone

5G7

Species Reactivity

Human; Rat

Immunogen

PHOX2A (NP_005160, 1 a.a. ~ 90 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

PHOX2A; paired-like homeobox 2a; aristaless (Drosophila) homeobox, aristaless homeobox (Drosophila), fibrosis of extraocular muscles, congenital, 2, autosomal recessive , ARIX, FEOM2, paired like (aristaless) homeobox 2a; paired mesoderm homeobox protein

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles.

Pathway

SIDS Susceptibility Pathways, organism-specific biosystem;