Human PHOX2A blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-PHOX2A/ARIX antibody

Target

PHOX2A / ARIX

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. [provided by RefSeq, Jul 2008]

Function

RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;

Synonyms

PHOX2A; paired-like homeobox 2a; aristaless (Drosophila) homeobox, aristaless homeobox (Drosophila), fibrosis of extraocular muscles, congenital, 2, autosomal recessive , ARIX, FEOM2, paired like (aristaless) homeobox 2a; paired mesoderm homeobox protein 2A; CFEOM2; PMX2A; arix homeodomain protein; ARIX1 homeodomain protein; aristaless homeobox homolog; aristaless homeobox protein homolog; ARIX; FEOM2; NCAM2; MGC52227;