PHC1; polyhomeotic homolog 1 (Drosophila); early development regulator 1 (homolog of polyhomeotic 1) , EDR1, polyhomeotic like 1 (Drosophila); polyhomeotic-like protein 1; HPH1; RAE28; polyhomeotic-like 1; early development regulatory protein 1; early de
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.
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