Anti-PGRMC1 (aa 185-195) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Macaque

Immunogen

Synthetic peptide: C-EPKDESARKND, corresponding to C terminal amino acids 185-195 of Human PGRMC1.

Conjugate

Application Notes

ICC/IF: 5 μg/ml; WB: 0.1 - 0.33 μg/ml;

Alternative Names

PGRMC1; progesterone receptor membrane component 1; MPR; HPR6.6; membrane-associated progesterone receptor component 1; progesterone binding protein;

Entrez Gene ID

UniProt ID

Antigen Description

PGRMC1 is a progesterone receptor component of 195 aa with a 26 residue N terminal hydrophobic region and no N terminal glycosylation site. It has an overall homology of 50% with PGRMC2 but their C terminal regions have a 68% homology, including a highly conserved 58 residue sequence.PGRMC1 is a heme bind proteins that is up-regulated in several cancers. In breast tumors, PGRMC1 is associated with hypoxia estrogen receptor-negative status. PGRMC1 is also shown to stimulate AKT phosphorylation and is known to stabilise the EGFR receptor tyrosine kinase.