Anti-PELO (aa 1-276) polyclonal antibody

In this paper, we deal with a frequent topic on morphological theory: the assignment of both structure and category to the verb+noun compound lavaplatos lit. 'wash+dishes' 'dish-washer'. Firstly, some of the problems identified in the previous approaches will be revised. Additionally, we will address new phonological and structural data that, if considered, make difficult to analyze the compound lavaplatos as related to constructions with nominalizers -traditionally, phrases like secador de pelo lit. 'dryer of hair' 'hair-dryer' or right-headed compounds like dish-washer-. In our proposal, the (optional) change of the verb phrase lavaplatos into a noun is obtained through a movement operation. We will show that this kind of approach helps us to explain the double character of lavaplatos compounds as name-givers to objects and predicates of their properties.

The HER family is composed of four receptor tyrosine kinases, which are frequently deregulated in several types of cancer. Activated HER receptors initiate intracellular signalling pathways by attracting to the plasma membrane a plethora of adaptor and signalling molecules. Although there are more than a dozen HER-interacting proteins that regulate signal transduction and have been extensively studied, recent proteomic studies have shown the existence of many novel but largely uncharacterized factors that may bind HER receptors. In this report, we describe a cell-based identification of several new HER2-binding proteins, including HAX1, YWHAZ, PELO and ACP1. Analysis of these factors showed that one of them, PELO, binds to active HER2 and epidermal growth factor receptor and thereby attenuates phosphatidylinositol 3-kinase (PI3K)/AKT signalling, likely through regulation of the recruitment of p85-PI3K to activated receptor. Functional characterization of PELO showed that it negatively regulates cell migration and metastasis in vivo. These results reveal that PELO is a novel regulator of HER-signalling and therefore is likely to have a role in inhibiting tumour progression and invasion.