Anti-PEG10 monoclonal antibody, clone 2C2D5

Name: Anti-PEG10 monoclonal antibody, clone 2C2D5
SKU: DCABH-12857
Rating: 5 (1 reviews)

Mouse anti-Human PEG10 monoclonal antibody for WB, IHC-P, IF, ELISA

COA

SDS

Datasheet

Summary

Specifications

Clone

2C2D5

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to amino acids 1-120 of human PEG10.

Conjugate

Unconjugated

Applications

Application Notes

ELISA (1:10000); WB (1:500-1:2000); Immunohistochemistry (1:200-1:1000); Immunofluorescence (1:200-1:1000) & The optimal working dilution should be determined by the end user.

Target

Alternative Names

PEG10; paternally expressed 10; retrotransposon-derived protein PEG10; HB 1; KIAA1051; Mar2; Mart2; MEF3L; RGAG3; MEF3 like 1; MEF3-like protein 1; ty3/Gypsy-like protein; paternally expressed gene 10 protein; retrotransposon gag domain containing 3; myel

Entrez Gene ID

23089

UniProt ID

Q86TG7

Product Background

Antigen Description

This gene includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family. The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frameshifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas.

Pathway

Validated targets of C-MYC transcriptional activation, organism-specific biosystem;

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

A retrotransposon-derived gene, PEG10, is a novel imprinted gene located on human chromosome 7q21

GENOMICS

Authors: Ono, R; Kobayashi, S; Wagatsuma, H; Aisaka, K; Kohda, T; Kaneko-Ishino, T; Ishino, F

Abstract

A novel paternally expressed imprinted gene, PEG10 (Paternally Expressed 10), was identified on human chromosome 7q21, PEG10 is located near the SGCE (Sarcoglycan epsilon) gene, whose mouse homologue was recently shown to be imprinted. Therefore, it is highly possible that a new imprinted gene cluster exists on human chromosome 7q21, Analysis of two predicted open reading frames (ORF1 and ORF2) revealed that ORF1 and ORF2 have homology to the gag and pol proteins of some vertebrate retrotransposons, respectively. These data suggest that PEG10 is derived from a retrotransposon that was previously integrated into the mammalian genome. PEG10 is likely to be essential for understanding how exogenous genes become imprinted. (C) 2001 Academic Press.

Prognostic value of PEG10 in Asian solid tumors: A meta-analysis

CLINICA CHIMICA ACTA

Authors: Ge, Hua; Yan, Yan; Wu, Di; Huang, Yongsheng; Tian, Fei

Abstract

Background The involvement of paternally expressed gene 10 (PEG10) in the development of solid tumors has been demonstrated. However, the available data have not yet been fully analyzed. We conducted this meta-analysis to evaluate the correlations between PEG10 and the clinicopathological characteristics in patients with solid tumors. Methods: An electronic search for relevant articles was conducted in PubMed, Web of Science, Cochrane Library, EMBASE, Chinese CNKI, and Wan Fang. The relationships between PEG10 and the clinicopathological features and prognosis of patients with cancer were determined using pooled odds ratios and hazard ratios with 95% confidence interval (CI). Results: Ten studies comprising 1014 patients were included. The pooled analyses indicated the significant association of PEG10 overexpression with the risk of cancer, differentiation, lymph node metastasis and advanced TNM stage, but not with gender in cancer patients. Moreover, a high level of PEG10 expression correlated with poor prognosis and could be used as an independent prognostic biomarker for patients with solid tumors. Conclusions: PEG10 expression is associated with advanced clinicopathological characteristics and can be used as a prognostic biomarker in patients with solid tumors.