Anti-PDZK1 (aa 1-50) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: MTSTFNPREC KLSKQEGQNY GFFLRIEKDT EGHLVRVVEK CSPAEKAGLQ, corresponding to a region within N terminal amino acids 1 - 50 of Human PDZK1 (XP_001126710)

Conjugate

Application Notes

ICC/IF: 5 μg/ml; WB: 1 μg/ml.

Alternative Names

PDZK1; PDZ domain containing 1; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; NHERF3; PDZD1; naPi-Cap1; PDZ-containing kidney protein 1; CFTR-associated protein of 70 kDa; sodium-hydrogen exchanger regulatory factor 3; na/Pi cotransporter C-terminal-as

Entrez Gene ID

UniProt ID

Antigen Description

A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.