Rabbit Anti-Human PDZK1 (C-terminal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse; Rat

Immunogen

A synthesized peptide derived from human PDZK1, corresponding to a region within C-terminal amino acids.

Conjugate

Application Notes

WB 1:500-1:2000
IHC 1:50-1:200
IF/ICC 1:100-1:500

General Notes

This product (Catalog No. DPABH-15923) is a rabbit-derived polyclonal antibody raised against human PDZK1. This antibody exhibits cross-reactivity with PDZK1 from mouse and rat. It has been affinity purified by Protein A. A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
DPABH-15923 is suitable for use in WB 1 (500-1:2000), IHC 1 (50-1:200), IF/ICC 1 (100-1:500) applications.
DPABH-15923 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Entrez Gene ID

UniProt ID