Specifications
Species Reactivity
Mouse; Human
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human PDX1.
Applications
Application Notes
WB: 1 μg/ml; ICC/IF: 5 μg/ml.
Target
Alternative Names
PDX1; pancreatic and duodenal homeobox 1; insulin promoter factor 1, homeodomain transcription factor; IPF1; pancreas/duodenum homeobox protein 1; IDX 1; MODY4; PDX 1; somatostatin transcription factor 1; STF 1; IPF-1; IUF-1; glucose-sensitive factor; ins
Product Background
Antigen Description
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5-[CT]TAAT[TG]-3. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.
Pathway
Developmental Biology; FOXA2 and FOXA3 transcription factor networks; Maturity onset diabetes of the young; Regulation of beta-cell development; Regulation of gene expression in beta cells; Regulation of gene expression in early pancreatic precursor cells
Citations
Publication ()
Have you cited DPABH-19903 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
