Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5-[CT]TAAT[TG]-3. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.
Pathway
Developmental Biology; FOXA2 and FOXA3 transcription factor networks; Maturity onset diabetes of the young; Regulation of beta-cell development; Regulation of gene expression in beta cells; Regulation of gene expression in early pancreatic precursor cells
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
Have you cited DPABH-19903 in a publication? Let us know and earn a reward for your research.
Faller, G; Kirchner, T; et al. Immunological and morphogenic basis of gastric mucosa atrophy and metaplasia. VIRCHOWS ARCHIV 446:1-9(2005).
Kunisada, Y; Tsubooka-Yamazoe, N; et al. Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells. STEM CELL RESEARCH 8:274-284(2012).
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COA
Certificate of Analysis
