Anti-PDX1 (N-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Cow; Dog; Human

Immunogen

Recombinant fusion protein containing N-Terminal region of mouse Pdx1

Conjugate

Application Notes

IHC-Fr: 1/5000; WB: 1/3000 - 1/5000; ICC/IF: 1/2000.

Alternative Names

PDX1; pancreatic and duodenal homeobox 1; pancreas/duodenum homeobox protein 1; islet/duodenum homeobox 1; somatostatin-transactivating factor 1; pancreatic and duodenal homeobox gene 1; insulin promoter factor 1, homeodomain transcription factor; Ipf1; I

Entrez Gene ID

UniProt ID

Antigen Description

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5-[CT]TAAT[TG]-3. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

Pathway

Developmental Biology; Maturity onset diabetes of the young; Regulation of beta-cell development; Regulation of gene expression in beta cells; Regulation of gene expression in early pancreatic precursor cells; Type II diabetes mellitus;