Anti-PDK4 (aa 181-280) polyclonal antibody

Species Reactivity

Human

Immunogen

PDK4 (AAH40239, 181 a.a. ~ 280 a.a) partial recombinant protein with GST tag. The sequence is SDSQTGNPSHIGSIDPNCDVVAVVQDAFGCSRMLCDQYYLSSPELKLTQANGKFPDQPIH IVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIV

Conjugate

Alternative Names

PDK4; pyruvate dehydrogenase kinase, isozyme 4; pyruvate dehydrogenase kinase, isoenzyme 4; pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase (

Entrez Gene ID

UniProt ID

Antigen Description

This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.

Pathway

Metabolism; Pyruvate metabolism and Citric Acid (TCA) cycle; The citric acid (TCA) cycle and respiratory electron transport;