This gene is a member of the PDK/BCKDK protein kinasefamily and encodes a mitochondrial protein with a histidine kinasedomain. This protein is located in the matrix of the mitrochondriaand inhibits the pyruvate dehydrogenase complex by phosphorylatingone of its subunits, thereby contributing to the regulation ofglucose metabolism. Expression of this gene is regulated byglucocorticoids, retinoic acid and insulin.
Pathway
Metabolism; Pyruvate metabolism; Pyruvate metabolism and Citric Acid (TCA) cycle; Regulation of pyruvate dehydrogenase (PDH) complex; The citric acid (TCA) cycle and respiratory electron transport
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