Anti-PDIA3 monoclonal antibody, clone Nbq.FSQ68 [FITC]

Antibody Isotype

IgG1

Clone

Nbq.FSQ68

Species Reactivity

Mouse; Rat; Rabbit; Guinea pig; Hamster; Dog; Human; Pig; Monkey

Immunogen

Recombinant full length protein corresponding to Human ERp57 aa 1-505.Sequence: MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLV EFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGY PTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFIS DKDASIVGFFDDSFSEAHSEFL

Conjugate

Application Notes

WB: 0.5 μg/ml;

Alternative Names

PDIA3; protein disulfide isomerase family A, member 3; glucose regulated protein, 58kDa , GRP58, protein disulfide isomerase associated 3; protein disulfide-isomerase A3; ERp57; ERp60; ERp61; GRP57; HsT17083; P58; PI PLC; ER protein 57; ER protein 60; ph

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.

Pathway

Adaptive Immune System, organism-specific biosystem; Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Antigen processing-Cross presentation, organism-specific biosystem; Asparagine N-linked glycosylation, organism-specific biosystem; Calnexin/calreticulin cycle, organism-specific biosystem;