A synthetic peptide of human PDIA3 is used for rabbit immunization.
Conjugate
Unconjugated
Target
Alternative Names
PDIA3; protein disulfide isomerase family A, member 3; glucose regulated protein, 58kDa , GRP58, protein disulfide isomerase associated 3; protein disulfide-isomerase A3; ERp57; ERp60; ERp61; GRP57; HsT17083; P58; PI PLC; ER protein 57; ER protein 60; pho
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.
Pathway
Adaptive Immune System, organism-specific biosystem; Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Antigen processing-Cross presentation, organism-specific biosystem; Asparagine N-linked glycosylation, organism-specific biosystem; Calnexin/calreticulin cycle, organism-specific biosystem;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Nemere, I; Garbi, N; et al. Intestinal Cell Calcium Uptake and the Targeted Knockout of the 1,25D(3)-MARRS (Membrane-associated, Rapid Response Steroid-binding) Receptor/PDIA3/Erp57. JOURNAL OF BIOLOGICAL CHEMISTRY 285:31859-U940(2010).
Fae, KC; da Silva, DD; et al. PDIA3, HSPA5 and vimentin, proteins identified by 2-DE in the valvular tissue, are the target antigens of peripheral and heart infiltrating T cells from chronic rheumatic heart disease patients. JOURNAL OF AUTOIMMUNITY 31:136-141(2008).
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COA
Certificate of Analysis
