PDE7A (NP_002594, 18 a.a. ~ 117 a.a) partial recombinant protein with GST tag. The sequence is TSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSV SARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQ
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Pathway
G Protein Signaling Pathways; GPCR downstream signaling; Morphine addiction; Purine metabolism
Citations
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