Anti-PDE3B polyclonal antibody (DPAB-DC1492)

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to rat Pde3b.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1:500; Immunostain: 1:200. & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
PDE3B; phosphodiesterase 3B, cGMP-inhibited; cGMP-inhibited 3,5-cyclic phosphodiesterase B; CGIPDE1; CGI-PDE B; phosphodiesterase 3B cGMP inhibited
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
catalyzes the hydrolysis of cAMP and cGMP; regulates insulin secretory processes [RGD, Feb 2006]The function about PDE3B antigen include 3,5-cyclic-AMP phosphodiesterase activity; 3,5-cyclic-nucleotide phosphodiesterase activity; cAMP binding; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity.
Pathway
Insulin signaling pathway; Morphine addiction; Progesterone-mediated oocyte maturation; Purine metabolism.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Hung, SH; Zhang, W; et al. New insights from the structure-function analysis of the catalytic region of human platelet phosphodiesterase 3A - A role for the unique 44-amino acid insert. JOURNAL OF BIOLOGICAL CHEMISTRY 281:29236-29244(2006).
Onuma, H; Osawa, H; et al. A newly identified 50 kDa protein, which is associated with phosphodiesterase 3B, is phosphorylated by insulin in rat adipocytes. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 337:976-982(2005).

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