PDE10A (NP_006652, 242 a.a. ~ 333 a.a) partial recombinant protein with GST tag. The sequence is GLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYS DLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQ
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5 monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.
Pathway
G alpha (s) signalling events; Hemostasis; Morphine addiction; Platelet homeostasis
Citations
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