Recombinant protein fragment, corresponding to a region within amino acids 99-324 of Human PAIP1 (Q9H074).
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/500 - 1/3000.
Target
Alternative Names
PAIP1; poly(A) binding protein interacting protein 1; polyadenylate-binding protein-interacting protein 1; PAIP-1; PABP-interacting protein 1; PABC1-interacting protein 1; poly(A)-binding protein-interacting protein 1; polyadenylate binding protein-intera
Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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McCallum, CD; Do, H; et al. The interaction of the chaperonin tailless complex polypeptide 1 (TCP1) ring complex (TRiC) with ribosome-bound nascent chains examined using photo-cross-linking. JOURNAL OF CELL BIOLOGY 149:591-601(2000).
Kanno, T; Sato, Y; et al. Expression of Kaposi's sarcoma-associated herpesvirus-encoded K10/10.1 protein in tissues and its interaction with poly(A)-binding protein. VIROLOGY 352:100-109(2006).
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COA
Certificate of Analysis