Anti-PAIP1 (aa 99-324) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant protein fragment, corresponding to a region within amino acids 99-324 of Human PAIP1 (Q9H074).

Conjugate

Application Notes

WB: 1/500 - 1/3000.

Alternative Names

PAIP1; poly(A) binding protein interacting protein 1; polyadenylate-binding protein-interacting protein 1; PAIP-1; PABP-interacting protein 1; PABC1-interacting protein 1; poly(A)-binding protein-interacting protein 1; polyadenylate binding protein-intera

Entrez Gene ID

UniProt ID

Antigen Description

Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.

Pathway

Deadenylation of mRNA; Deadenylation-dependent mRNA decay; Gene Expression; RNA transport; Translation Factors;