Anti-PAIP1 monoclonal antibody, clone FQS24360

Antibody Isotype

IgG

Clone

FQS24360

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human PAIP1 aa 400 to the C-terminus (Cysteine residue). The exact sequence is proprietary.Database link: Q9H074

Conjugate

Application Notes

WB: 1/1000 - 1/5000; IHC-P: 1/50 - 1/100; ICC/IF: 1/50 - 1/100; IP: 1/10 - 1/100; Flow Cyt: 1/10 - 1/100;

Alternative Names

PAIP1; poly(A) binding protein interacting protein 1; polyadenylate-binding protein-interacting protein 1; PAIP-1; PABP-interacting protein 1; PABC1-interacting protein 1; poly(A)-binding protein-interacting protein 1; polyadenylate binding protein-intera

Entrez Gene ID

UniProt ID

Antigen Description

Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.

Pathway

Deadenylation of mRNA, organism-specific biosystem; Deadenylation-dependent mRNA decay, organism-specific biosystem; Gene Expression, organism-specific biosystem; RNA transport, organism-specific biosystem; RNA transport, conserved biosystem; Translation Factors, organism-specific biosystem;