Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide within Human Peroxiredoxin 1/PAG aa 150 to the C-terminus (C terminal). The exact sequence is proprietary.
Applications
Application Notes
Recommended concentration:
ICC/IF: 1/100
WB: 1/10000 - 1/50000
FC: use at an assay dependent concentration.
Target
Alternative Names
PAG1; phosphoprotein associated with glycosphingolipid microdomains 1; phosphoprotein associated with glycosphingolipid-enriched microdomains 1; CBP; Csk binding protein; PAG; transmembrane adaptor protein PAG; Csk-binding protein; transmembrane phosphopr
Product Background
Antigen Description
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Pathway
Adaptive Immune System, organism-specific biosystem; BCR signaling pathway, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Disease, organism-specific biosystem; GAB1 signalosome, organism-specific biosystem; Immune System, organism-specific biosystem; Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystem.
Citations
Publication ()
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COA
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