KLH conjugated syntHetic peptide corresponding to aa 323-339 of Ovalbumin.
Conjugate
Biotin
Target
Alternative Names
OVA; Rabbit Anti-OVA Polyclonal Antibody; Anti-OVA Polyclonal Antibody; OVA Polyclonal Antibody Rabbit Anti-OVA PAb; Anti-OVA PAb; OVA PAb; Rabbit Anti-OVA Antibody; Anti-OVA Antibody; OVA Antibody
Citations
Publication ()
Have you cited DPAB27550 in a publication? Let us know and earn a reward for your research.
Background
Ovalbumin (OVA) is an N-linked glycoprotein consisting of 385 amino acid residues and is the main component of egg white, accounting for more than 60%. Its chemical structure includes 6 disulfide bonds and a free thiol group, which endows it with strong antioxidant activity and good solubility. OVA (and OVA mRNA) has broad application prospects in vaccine development, gene expression research, protein production, and immunological studies. Its multifunctionality makes it an important tool for the research and development of various biomedical and biotechnological products.
OVA is often used as a model antigen. It can sensitize and induce experimental animals to produce specific immunity, facilitating the observation of antigen presentation, T-cell and B-cell activation, and other processes in related allergic mechanisms. OVA is well-recognized by the animal immune system, inducing high levels of antibodies with good reproducibility of symptoms. Its mouse allergy model is widely used in the field of food allergies and other autoimmune diseases to determine the causes, mechanisms, and strategies for prevention or treatment. OVA's application as a drug delivery carrier is also significant. It often carries major antigens, delivering them in the form of complexes to enhance the immunogenicity of the primary antigen. It is easily accessible, cost-effective, and sensitive to pH and temperature changes. OVA is also commonly used to test and evaluate new vaccine adjuvants. Combining OVA with adjuvants allows for the observation of how different adjuvants enhance vaccine efficacy, facilitating selection. OVA can also form a gel network used as a stabilizer, stabilizing emulsions and foams.
OVA can bind to metal ions, aiding in the preparation of template-based nanoparticles. For example, OVA can bind with gold, silver, and palladium in solution to form uniformly distributed metal-protein complexes. After reduction, these can produce metal nanoparticles with precise specific sizes and shapes. These uniform nanoparticles exhibit excellent catalytic performance and can be used as catalysts or catalyst carriers in redox reactions, or for photocatalytic reactions in environmental remediation and energy conversion fields. Additionally, these template metal nanoparticles have high sensitivity and specificity, making them useful in medical diagnostics for detecting biomolecules such as proteins, DNA, and glucose. Moreover, OVA can encapsulate metal nanoparticles, helping them remain stable in vivo, which is significant for medical applications like bioimaging.
My Review for Anti-OVA (aa 323-339) polyclonal antibody [Biotin]
Creative Diagnostics products are for RESEARCH USE ONLY, please make sure your review is research based.
Required fields are marked with *
Terms and conditions:
We will select high-quality review customers and offer a $30 coupon for your next purchase.
All product reviews must be submitted in the English language.
Creative Diagnostics will not share any personal information of applicants, and all information will be treated with strict confidentiality and will not be sold or disclosed to a third party.
References
Which One Is More Prominent in Recurrent Hydatidiform Mole, Ovum or Sperm?
Recurrent hydatidiform mole is defined as episodes of two molar pregnancies in a female. Often, complete moles only derive androgenic nuclear genome. We described two cases with repeated molar pregnancies attempted to prevent future episodes by performing intracytoplasmic sperm injection (ICSI) and preimplantation genetic diagnosis (PGD) to assess genetic disorders. The first patient had previously six complete molar pregnancies and advised to carry out ICSI with ovum donation to achieve a normal pregnancy. The second case had previously five molar pregnancies and no XY embryos from the ICSI/PGD process. We had to (at the insistence of the patient) transfer XX embryos in this patient which resulted in a complete hydatidiform mole (CHM). Hence, available data based on our patients and previous studies demonstrated that oocyte might play a critical role in the pathophysiology of recurrent hydatidiform mole, while it has not been often considered.
Cortistatin protects against inflammatory airway diseases through curbing CCL2 and antagonizing NF-kappa B signaling pathway
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Asthma is a chronic inflammatory disease affecting millions of people around the world, yet much remains unknown about its underlying mechanisms. Cortistatin (CST) is a neuropeptide which is reported to be a potential endogenous anti-inflammatory factor in several conditions. To testify the potential involvement of CST in airway inflammatory reaction, an ovalbumin (OVA)-induced mice model was established in wild-type (WT) as well as CST-knockout (Cort(-/-)) mice. Thereafter, lung tissue or cell samples were gathered in each group, and histological analysis as well as cell counting assay indicated that Cort(-/-) mice exhibited exaggeration of asthma compared with WT control group. Moreover, mRNA sequencing assay revealed that CCL2 was a potential target of CST in asthma, and administration of CCL2 inhibitor alleviated airway inflammation of asthma in Cort(-/-) mice. Moreover, NF-kappa B signaling pathway might be closely associated with the protective function of CST in asthma, as enhanced activation of NFkB signaling pathway was observed in OVA-induced asthma model of Cort(-/-) mice, and SN50, an inhibitor of NF-kappa B signaling pathway, antagonized asthma development in Cort(-/-) mice. In summary, CST might represent as a promising target for the treatment of asthma through interacting with CCL2 and NF-kappa B signaling pathway. (C) 2020 Elsevier Inc. All rights reserved.
COA
Publication 
Loading ......
