Anti-OTUD5 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human OTUD5 is used for rabbit immunization.

Conjugate

Alternative Names

OTUD5; OTU deubiquitinase 5; DUBA; OTU domain-containing protein 5; OTU domain containing 5; deubiquinating enzyme A; deubiquitinating enzyme A;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.

Pathway

Gastric cancer network 2; Immune System; Innate Immune System; Negative regulators of RIG-I/MDA5 signaling; RIG-I-like receptor signaling pathway; RIG-I-like receptor signaling pathway; RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways;