Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
Pathway
Metabolism; Sphingolipid de novo biosynthesis;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
Have you cited DPABH-22592 in a publication? Let us know and earn a reward for your research.
Moreira, EF; Jaworski, C; et al. Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina. JOURNAL OF BIOLOGICAL CHEMISTRY 276:18570-18578(2001).
Bowling, N; Matter, WF; et al. LY295427, a novel hypocholesterolemic agent, enhances [H-3]25-hydroxycholesterol binding to liver cytosolic proteins. JOURNAL OF LIPID RESEARCH 37:2586-2598(1996).
Payment methods we support:
Invoice / Purchase Order
Credit card
My Review for Anti-OSBP polyclonal antibody
Creative Diagnostics products are for RESEARCH USE ONLY, please make sure your review is research based.
Required fields are marked with *
Terms and conditions:
We will select high-quality review customers and offer a $30 coupon for your next purchase.
All product reviews must be submitted in the English language.
Creative Diagnostics will not share any personal information of applicants, and all information will be treated with strict confidentiality and will not be sold or disclosed to a third party.
COA
Certificate of Analysis
