Specifications
Immunogen
Synthetic peptide corresponding to Human ORC3 aa 698-711 (C terminal).Sequence: QKTDHVARLTWGGC Database link: Q9UBD5
Applications
Application Notes
WB: 1 - 3 μg/ml; IHC-P: 3.75 μg/ml.
Target
Alternative Names
ORC3; origin recognition complex, subunit 3; ORC3L, origin recognition complex, subunit 3 (yeast homolog) like; origin recognition complex, subunit 3 honolog (yeast); origin recognition complex, subunit 3 like (yeast); origin recognition complex subunit 3
Product Background
Antigen Description
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Pathway
Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the ORC complex at the origin of replication; Assembly of the pre-replicative complex; Association of licensing factors with the pre-replicative co
Citations
Publication ()
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COA
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