Anti-ORC3 monoclonal antibody, clone 2E7

Antibody Isotype

IgG2b

Clone

2E7

Species Reactivity

Human

Immunogen

Full length human ORC3L protein.

Conjugate

Alternative Names

ORC3; origin recognition complex, subunit 3; ORC3L, origin recognition complex, subunit 3 (yeast homolog) like , origin recognition complex, subunit 3 honolog (yeast) , origin recognition complex, subunit 3 like (yeast); origin recognition complex subu

Entrez Gene ID

UniProt ID

Antigen Description

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.

Pathway

Activation of ATR in response to replication stress, organism-specific biosystem; Activation of the pre-replicative complex, organism-specific biosystem; Assembly of the ORC complex at the origin of replication, organism-specific biosystem; Assembly of the pre-replicative complex, organism-specific biosystem; Association of licensing factors with the pre-replicative complex, organism-specific biosystem; CDC6 association with the ORC:origin complex, organism-specific biosystem; CDT1 association with the CDC6:ORC:origin complex, organism-specific biosystem;