General Notes
This product (Catalog No. DPABH-23434) is a rabbit-derived polyclonal antibody raised against human OPA1, targeting the amino acid region 607–960 of the protein. This antibody exhibits cross-reactivity with Human OPA1 from mouse and rat. It has been affinity purified by Protein A. The Dynamin-like 120 kDa protein, also known as OPA1 (optic atrophy 1), is a dynamin-related GTPase encoded by the OPA1 gene on chromosome 3q29 that localizes to the inner mitochondrial membrane, where it plays a central role in maintaining mitochondrial morphology, fusion, and cristae structure. This protein exists in multiple isoforms generated by alternative splicing and proteolytic processing, with long isoforms (L-OPA1) anchoring to cristae junctions to sequester proapoptotic cytochrome c and short isoforms (S-OPA1) facilitating stress-induced remodeling and fragmentation.
DPABH-23434 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-23434 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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