Anti-OBSCN (aa 1551-1649) polyclonal antibody

Species Reactivity

Human

Immunogen

OBSCN (XP_290923, 1551 a.a. ~ 1649 a.a) partial recombinant protein with GST tag. The sequence is KAGMGPYSSPSEQVLLGGPSHLASEEESQGRSAQPLPSTKTFAFQTQIQRGRFSVVRQCW EKASGRALAAKIIPYHPKDKTAVLREYEALKGLRHPHLA

Conjugate

Alternative Names

OBSCN; obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF; UNC89; ARHGEF30; obscurin; obscurin-MLCK; obscurin, myosin light chain kinase;

Entrez Gene ID

UniProt ID

Antigen Description

The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified.

Pathway

Cell death signalling via NRAGE, NRIF and NADE; GPCR downstream signaling; Regulation of RhoA activity; Signal Transduction