Synthetic phosphopeptide conjugated to KLH, surrounding the phosphorylation site of Tyrosine 515 (P-Q-Y(p)-F-G) derived from Human TrkB (NP_001007098.1).
Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
Pathway
Activation of TRKA receptors; Alcoholism; MAPK signaling pathway; NGF signalling via TRKA from the plasma membrane
Citations
Publication ()
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