General Notes
This product (Catalog No. DPABH-01932) is a rabbit-derived polyclonal antibody raised against human NRP2, targeting the amino acid region 231–490 of the protein. This antibody exhibits cross-reactivity with Human NRP2 from mouse and rat. It has been affinity purified by Protein A. Neuropilin-2 (NRP2) is a type I transmembrane glycoprotein that serves as a co-receptor in multiple signaling pathways, primarily facilitating axon guidance in the nervous system and vascular development through interactions with semaphorins and vascular endothelial growth factors (VEGFs). Structurally, NRP2 consists of a large extracellular domain with two CUB domains (a1 and a2), two coagulation factor VIII-homologous domains (b1 and b2), a meprin-mu (MAM) domain, a transmembrane region, and a short cytoplasmic tail of approximately 40-43 amino acids, with alternative splicing producing variants such as NRP2A and NRP2B that differ in their C-terminal sequences. The gene encoding NRP2 is located on human chromosome 2q34 and spans about 115 kb across 20 exons, sharing evolutionary origins with the neuropilin-1 (NRP1) gene through duplication.
DPABH-01932 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-01932 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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