General Notes
This product (Catalog No. DPABH-23687) is a rabbit-derived polyclonal antibody raised against human NRP2. This antibody exhibits cross-reactivity with NRP2 from mouse and rat. It has been affinity purified by Protein A. Neuropilin-2 (NRP2) is a type I transmembrane glycoprotein that serves as a co-receptor in multiple signaling pathways, primarily facilitating axon guidance in the nervous system and vascular development through interactions with semaphorins and vascular endothelial growth factors (VEGFs). Structurally, NRP2 consists of a large extracellular domain with two CUB domains (a1 and a2), two coagulation factor VIII-homologous domains (b1 and b2), a meprin-mu (MAM) domain, a transmembrane region, and a short cytoplasmic tail of approximately 40-43 amino acids, with alternative splicing producing variants such as NRP2A and NRP2B that differ in their C-terminal sequences. The gene encoding NRP2 is located on human chromosome 2q34 and spans about 115 kb across 20 exons, sharing evolutionary origins with the neuropilin-1 (NRP1) gene through duplication.
DPABH-23687 is suitable for use in WB 1 (500-1:2000), IHC 1 (50-1:200) applications.
DPABH-23687 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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