Specifications
Species Reactivity
Mouse; Human
Immunogen
Recombinant fragment, corresponding to amino acids 134-274 of Human NQO1
Applications
Application Notes
WB: 1/500 - 1/2000; IHC-P: 1/200 - 1/1000; Flow Cyt: 1/200 - 1/400;
Target
Alternative Names
NQO1; NAD(P)H dehydrogenase, quinone 1; DIA4, diaphorase (NADH/NADPH) (cytochrome b 5 reductase) , NMOR1; NAD(P)H dehydrogenase [quinone] 1; DHQU; DTD; QR1; azoreductase; diaphorase-4; DT-diaphorase; dioxin-inducible 1; menadione reductase; quinone reduc
Product Background
Antigen Description
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
Pathway
Keap1-Nrf2 Pathway, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Oxidative Stress, organism-specific biosystem; Regulation of ornithine decarboxylase (ODC), organism-specific biosystem;
Citations
Publication ()
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COA
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