Anti-NPR2 (aa 131-230) polyclonal antibody

Species Reactivity

Human

Immunogen

NPR2 (AAH34917, 131 a.a. ~ 230 a.a) partial recombinant protein with GST tag. The sequence is AKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEA LQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPL

Conjugate

Alternative Names

NPR2; natriuretic peptide receptor 2; AMDM; ANPb; NPRB; ANPRB; GUC2B; NPRBi; GUCY2B; atrial natriuretic peptide receptor 2; GC-B; ANP-B; NPR-B; ANPR-B; guanylate cyclase B; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor ty

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.

Pathway

Oxytocin signaling pathway; Vascular smooth muscle contraction;