Anti-NOS1 (aa 1041-1150) polyclonal antibody

Species Reactivity

Human

Immunogen

NOS1 (NP_000611, 1041 a.a. ~ 1150 a.a) partial recombinant protein with GST tag. The sequence is FPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIFQAFK YYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNPT

Conjugate

Alternative Names

NOS1; nitric oxide synthase 1 (neuronal); NOS; bNOS; nNOS; IHPS1; N-NOS; NC-NOS; nitric oxide synthase, brain; NOS type I; neuronal NOS; constitutive NOS; peptidyl-cysteine S-nitrosylase NOS1;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5 UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]

Pathway

Alzheimers disease; Amyotrophic lateral sclerosis (ALS); Calcium signaling pathway; Disease