Anti-NMNAT3 (aa 149-162) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: C-QHNIHLAKEPVQNE, corresponding to internal sequence amino acids 149-162 of Human NMNAT3 isoform 2 and 186-199 of Human NMNAT3 isoform 1 (NP_001186976.1. NP_835471.1).

Conjugate

Application Notes

WB: 0.1 - 0.3 μg/ml.

Alternative Names

NMNAT3; nicotinamide nucleotide adenylyltransferase 3; nicotinamide mononucleotide adenylyltransferase 3; PNAT3; NMN adenylyltransferase 3; NaMN adenylyltransferase 3; pyridine nucleotide adenylyltransferase 3; nicotinate-nucleotide adenylyltransferase 3;

Entrez Gene ID

UniProt ID

Antigen Description

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury.

Pathway

Metabolic pathways; Metabolism; Metabolism of vitamins and cofactors; Metabolism of water-soluble vitamins and cofactors; NAD biosynthesis II (from tryptophan); NAD biosynthesis III; NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde