NFKBIE (NP_004547, 403 a.a. ~ 498 a.a) partial recombinant protein with GST tag. The sequence is SGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGAD SLLRNVEDETPQDLTEESLVLLPFDDLKISGKLLLC
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus.
Pathway
Activation of NF-kappaB in B cells; Adipocytokine signaling pathway; Apoptosis; B cell receptor signaling pathway
Citations
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