Anti-NEDD8 monoclonal antibody, clone OE34

Antibody Isotype

IgG2b

Clone

OE34

Species Reactivity

Human

Immunogen

Synthetic peptide: TDKVERIKERVEE conjugated to KLH, corresponding to amino acids 20-32 of Human NEDD8

Conjugate

Alternative Names

NEDD8; neural precursor cell expressed, developmentally down-regulated 8; Nedd 8; neddylin; ubiquitin-like protein Nedd8; NEDD-8; FLJ43224; MGC104393; MGC125896; MGC125897;

Entrez Gene ID

UniProt ID

Antigen Description

Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.

Pathway

p53 pathway, organism-specific biosystem;