Anti-NDUFS1 monoclonal antibody, clone FQS22633(C)

Antibody Isotype

IgG

Clone

FQS22633(C)

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide, corresponding to residues in Human Ndufs1 (UniProt: P28331).

Conjugate

Application Notes

WB: 1/10000 - 1/50000; Flow Cyt: 1/10 - 1/100; ICC/IF: 1/50 - 1/100; IHC-P: 1/100 - 1/250;

Alternative Names

NDUFS1; NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 1 (75kD) (NADH coenzyme Q reductase); NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; CI 75k; complex I 7

Entrez Gene ID

UniProt ID

Antigen Description

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized.

Pathway

Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Electron Transport Chain, organism-specific biosystem; Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem;