This product (Catalog No. DPABH-03964) is a rabbit-derived polyclonal antibody raised against human NARF. It has been affinity purified by Protein A. Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. DPABH-03964 is suitable for use in IF (immunofluorescence) (1:40–1:200) application. DPABH-03964 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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References
Eukaryotic Fe-hydrogenases - old eukaryotic heritage or adaptive acquisitions?
All eukaryotes seem to possess proteins that most probably evolved from an ancestral Fe-hydrogenase. These proteins, known as NARF or Nar, do not produce hydrogen. Notably, a small group of rather unrelated unicellular anaerobes and a few algae possess Fe-hydrogenases, which produce hydrogen. In most, but not all organisms, hydrogen production occurs in membrane-bounded organelles, i.e. hydrogenosomes or plastids. Whereas plastids are monophyletic, hydrogenosomes evolved repeatedly and independently from mitochondria or mitochondria-like organelles. A systematic analysis of the various hydrogenosomes and their hydrogenases will contribute to an understanding of the evolution of the eukaryotic cell, and provide clues to the evolutionary origin(s) of the Fe-hydrogenase.
Evaluating and Comparing of 3D Shape Descriptors for Object Recognition
In this work we show the results of a system for object recognition by using depth data. It is based on shape descriptors and PCA reduction. For obtaining the results, we evaluated different combination of three descriptors that are suitable for this work: Spin Images, VFH (Viewpoint Feature Histogram) and NARF (Normal Aligned Radial Feature). In addition, we created a method for extracting the NARF descriptor in order to obtain a global descriptor. The results show that the combination of descriptors can be used for object recognition in a database composed of point clouds obtained with a RGB-D sensor.
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