Anti-MYLK4 monoclonal antibody, clone 8B4

Antibody Isotype

IgG2a

Clone

8B4

Species Reactivity

Human

Immunogen

MYLK4 (NP_001012418.1, 3 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

MYLK4; myosin light chain kinase family, member 4; myosin light chain kinase family member 4; caMLCK like; SgK085; sugen kinase 85;

Entrez Gene ID

UniProt ID

Antigen Description

Myosin light chain kinase 4 also known as MYLK4 is an enzyme which in humans is encoded by the MYLK2 gene. MYLK4 is a member of the myosin light-chain kinase family of serine/threonine-specific protein kinases that phosphorylate the regulatory light chain of myosin II. This protein acts as an enzyme that catalyzes the following reaction: ATP + a protein -> ADP + a phosphoprotein. MYLK4 is also involved in protein amino acid phosphorylation meaning that it adds a phosphate group onto the molecule. Not very much is known about the specific functional characteristics of MLYK4, but it has recently been found that the gene may possibly have a role in having at least one driver mutation for cancer. MYLK4 may also be involved in transferase activity, ATP binding, protein serine/threonine kinase activity, and also nucleotide binding. Other names for MYLK4 are CaMLCK like; EG238564; MYLK4; Mylk4; Myosin light chain kinase family, member 4; SgK085; SGK085; Sgk085; Sugen kinase 85; Uncharacterized serine/threonine-protein kinase SgK085. The "Sgk" in the Sgk085 name for MYLK4 stands for to serum- and glucocorticoid-inducible kinases. These are serine/threonine protein kinases (SGKs) whose transcription is kept in check by cell volume, corticoids, and serum.