Anti-MYL12A polyclonal antibody (DPABH-25170)

Rabbit anti-Human MYL12A (aa 16-20) polyclonal antibody for WB, ICC/IF

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Mouse, Rat, Human
Immunogen
Synthetic peptide conjugated to KLH, surrounding amino acids 16-20 (A-T-S-N-V) of Human MRCL3 (NP_006462.1).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500 - 1/1000; ICC/IF: 1/100 - 1/200.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
MYL12A; myosin, light chain 12A, regulatory, non-sarcomeric; MLCB; MRCL3; MRLC3; MYL2B
Entrez Gene ID
UniProt ID

Product Background


Gene summary
MYL12A (Myosin Light Chain 12A) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Regulation of actin cytoskeleton. GO annotations related to this gene include calcium ion binding and glutamate receptor binding. An important paralog of this gene is MYLPF. This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.
Antigen Description
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). Myosin regulatory light chain 12A is a protein that in humans is encoded by the MYL12A gene. 0The function about MYL12A antigen include calcium ion binding; glutamate receptor binding; protein binding.
Pathway
Focal adhesion; Leukocyte transendothelial migration; Platelet activation; Regulation of actin cytoskeleton.

Citations


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References


Dabrowska, M; Skoneczny, M; et al. Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. TUMOR BIOLOGY 32:965-976(2011).
Park, I; Han, C; et al. Myosin regulatory light chains are required to maintain the stability of myosin II and cellular integrity. BIOCHEMICAL JOURNAL 434:171-180(2011).

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