This gene encodes a component of BLOC-1 (biogenesis of lysosome-related organelles complex 1). Components of this complex are involved in the biogenesis of organelles such as melanosomes and platelet-dense granules. A mouse model for Hermansky-Pudlak Syndrome is mutated in the murine version of this gene. Some transcripts of the downstream gene TXNDC5 overlap this gene, but they do not contain an open reading frame for this gene.
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References
Private and public debt interlinkages in bad times
Drawing on a large sample of recession episodes, we document that those preceded by larger buildups in private debt tend to be followed by larger accumulations of public debt. Similarly to recessions preceded by a rapid run-up in public debt, these ex-post public debt buildups are associated with a more muted growth in government expenditures and a sharper rise in fiscal stress. The documented pattern becomes particularly intense in financial crises and emerges in both low and high public debt environments. These empirical regularities suggest that private sector indebtedness should be considered a relevant factor in the assessment of the soundness of the fiscal position. (C) 2020 Elsevier Ltd. All rights reserved.
Does policy motivation drive party activism? A study of party activists in three Asian democracies
Studies of party activism highlight that party activists are driven by various motivations and that these affect their level of activism. However, it remains unclear whether policy-motivated activists are more engaged in party activities than those motivated by other incentives and whether the motivation-activism link varies with party characteristics. This article investigates these questions by focusing on political actors linking parties and voters in the local community. I use a party activist survey data set collected during recent national election campaigns in three Asian young democracies: Taiwan, Korea, and Mongolia. The results demonstrated the prominence of policy motivation as an impetus for activists' intraparty commitment. I also found that the positive effect of policy motivation is especially robust in small parties, while it is muted in large parties and that party membership increases the probability of intraparty commitment, challenging the widely held belief that formal membership is pointless in Asian parties.
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