Anti-MRE11A (N-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

MRE11 antibody was raised against a 14 amino acid peptide from near the amino terminus human MRE11.

Conjugate

Alternative Names

MRE11A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae); ATLD; HNGS1; MRE11; MRE11B; double-strand break repair protein MRE11A; AT-like disease; MRE11 homolog 1; MRE11 homolog A; endo/exonuclease Mre11; meiotic recombination 11 homolog 1; meiotic

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Pathway

Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks; BARD1 signaling events; BRCA1-associated genome surveillance complex (BASC); Cell Cycle; Cellular Senescence; Cellular responses to stress; Cytosolic sensors of pathogen-associated DNA; DNA Damage/Telomere Stress Induced Senescence