Recombinant full length protein corresponding to Human MNAT1 aa 1-309.Sequence: MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECG TPLRKSNFRVQLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLE EVEEIVFNLTNNVDLDNTKKKMEIYQKENKDVIQKNKLKLTREQEELEEA LEVERQENEQRRLFIQKEEQLQ
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/500 - 1/2000; IHC-P: 1/50 - 1/200;
Target
Alternative Names
MNAT1; MNAT CDK-activating kinase assembly factor 1; MAT1; TFB3; CAP35; RNF66; CDK-activating kinase assembly factor MAT1; RING finger protein 66; RING finger protein MAT1; CDK7/cyclin-H assembly factor; cyclin G1 interacting protein; cyclin-G1-interactin
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
Pathway
Basal transcription factors; Cell Cycle; Cyclin A/B1 associated events during G2/M transition; Cyclin D associated events in G1
Citations
Publication ()
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