The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene.
Pathway
Basal transcription factors; Cell Cycle; Cell Cycle, Mitotic; Cyclin A/B1 associated events during G2/M transition; Cyclin A:Cdk2-associated events at S phase entry; Cyclin D associated events in G1; Cyclin E associated events during G1/S transition; DNA Repair; Disease; Dual incision reaction in GG-NER; Dual incision reaction in TC-NER;
Citations
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