Rabbit Anti-Mouse MMP12 (a.a. 151-250) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat

Immunogen

KLH conjugated synthetic peptide derived from mouse MMP12: 151-250/473

Conjugate

Application Notes

WB: 1:500-2000

General Notes

This product (Catalog No. DPABH-00470) is a rabbit-derived IgG polyclonal antibody raised against mouse MMP12, targeting the amino acid region 151–250 of the protein. This antibody exhibits cross-reactivity with MMP12 from rat. It has been affinity purified by Protein A. This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein have a diminished capacity to degrade extracellular matrix components, do not develop emphysema in response to long-term exposure to cigarette smoke, and exhibit impaired clearance and increased mortality upon bacterial infection. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. Alternate splicing generates multiple transcript variants encoding distinct isoforms.
DPABH-00470 is suitable for use in Western blot (WB) (1:500–1:2,000) application.
DPABH-00470 is supplied as a liquid formulation in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

matrix metalloproteinase 12; MMP12; EC 3.4.24.65; HME; Macrophage elastase; Macrophage metaloelastase; Matrix metalloprotease 12; ME; MGC138506; MME; MMP 12; MMP12_HUMAN; MMP 12; MMP-12; MMP12

Entrez Gene ID

UniProt ID