Anti-MICA + MICB monoclonal antibody, clone 7E5 [FITC]

Antibody Isotype

IgG2a

Clone

7E5

Species Reactivity

Human

Immunogen

MICA transfected C1R cells.

Conjugate

Application Notes

Flow Cyt Use 10μl for 10⁶ cells.

Alternative Names

MICA; MHC class I polypeptide-related sequence A; PERB11.1; HLA class I antigen; stress inducible class I homolog; MHC class I chain-related protein A; MIC-A; FLJ36918; FLJ60820; MGC21250; MGC111087;

Entrez Gene ID

UniProt ID

Antigen Description

Human nonclassical MHC class I chain-related protein A (MICA) and B (MICB)are also known as PERB11.1 and PERB11.2. MICA/B are 65-75 kD stress-inducible glycoproteins with highly polymorphic. They are MHC class I-like transmembrane molecules that do not associate β2-microglobulin and do not present peptides. MICA and MICB share 85% identify, and are mainly expressed on Intestinal epithelial cells, epithelial tumor cells, endothelial cells, fibroblasts, and IFN-a-stimulated dendritic cells. MIC molecules bind NKG2D, an activating receptor, and induce activation of NK cells, and subset of CD8+ alpha/beta T cells and gamma/delta T cells, as well as suppression of T cell proliferation. MICA/B recognition is involved in the regulation of tumor surveillance, viral infection and autoimmune diseases.

Pathway

Natural killer cell mediated cytotoxicity, organism-specific biosystem; Natural killer cell mediated cytotoxicity, conserved biosystem.