Anti-H2-D1 monoclonal antibody, clone TG2-2.2.2 Functional Grade

Antibody Isotype

IgG2a

Clone

TG2-2.2.2

Species Reactivity

Mouse

Immunogen

The details of the immunogen for this antibody are not available. corresponding to Mouse MHC Class I H2 Kd.

Conjugate

Application Notes

Flow Cyt: 0.125μg/10⁶ cells.

Alternative Names

H2-K1; histocompatibility 2, K1, K region; H-2 class I histocompatibility antigen, K-W28 alpha chain; H-2K(B); H-2K(K); H-2K(Q); MHC class I antigen; MHC class I heavy chain H2-K; MHC H2-K transplantation antigen; class I major histocompatibility antigen

Entrez Gene ID

UniProt ID

Antigen Description

MHC Class I H2 Kd is involved in the presentation of foreign antigens to the immune system. The "classical" MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant Beta2-microglobulin. These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny.

Pathway

Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem;