Anti-H2-D1 monoclonal antibody, clone 45-2-3T [FITC]

Antibody Isotype

IgG2a

Clone

45-2-3T

Species Reactivity

Mouse

Immunogen

Tissue/ cell preparation of C3H.SW splenocytes (Mouse)

Conjugate

Application Notes

Flow Cyt: 1μg/10⁶ cells.

Alternative Names

H2-D1; histocompatibility 2, D region locus 1; H-2 class I histocompatibility antigen, L-D alpha chain; Q5k protein; MHC class I H-2Dp; MHC H2-D-q alpha-chain; MHC class I H2 antigen; H-2D cell surface glycoprotein; H2-DC1-beta transplantation antigen pro

Entrez Gene ID

UniProt ID

Antigen Description

The "classical" MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant beta 2-microglobulin. These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny.

Pathway

Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem;