Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse MFG-E8. Ala23-Cys463 Accession Number P21956
Applications
Application Notes
Western Blot: 0.1 μg/mL; ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4064 - DPABY-642
Target
Alternative Names
MFGE8; milk fat globule-EGF factor 8 protein; P47; MP47; Mfgm; SED1; MFG-E8; AA408458; AI325141; lactadherin; lactadherin; EGF/factor VIII; sperm surface protein SP47; milk fat globule glycoprotein;
Product Background
Antigen Description
MFG-E8, originally identified as a product of lactating mammary glands, is also secreted by activated macrophages and immature dendritic cells. MFG-E8 functions as an opsonin by binding phosphatidylserine on apoptotic cells and enhancing their phagocytosis.
Pathway
Amyloids; Disease;
Citations
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Watanabe, T; Totsuka, R; et al. Production of the long and short forms of MFG-E8 by epidermal keratinocytes. CELL AND TISSUE RESEARCH 321:185-193(2005).
Fricker, M; Neher, JJ; et al. MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation. JOURNAL OF NEUROSCIENCE 32:2657-2666(2012).
COA
Certificate of Analysis
