Transcriptional activator which binds specifically to the MEF2 element, 5-YTA[AT](4)TAR-3, found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis.
Pathway
Adipogenesis; CDO in myogenesis; Circadian Clock; Developmental Biology; Energy Metabolism; Myogenesis; Role of Calcineurin-dependent NFAT signaling in lymphocytes
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